منابع مشابه
Structure-based drug design: computational advances.
Structure-based computational methods continue to enhance progress in the discovery and refinement of therapeutic agents. Several such methods and their applications are described. These include molecular visualization and molecular modeling, docking, fragment methods, 3-D database techniques, and free-energy perturbation. Related issues that are discussed include the use of simplified potentia...
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CONTENTS PERSPECTIVES AND OVERVIEW .............................•...................... ........... . . ................ . . . .... 70 The Molecules: a Brief Review . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 70 Two Strategies . . . . . . . . . . . . . . . . . . . . . . . . . . ...
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The polysulfone-based membrane has been used in hemodialysis (HD) and it is continuously developed to maintain its sustainability on the subject of biocompatibility. During the polysulfone-based membrane development, several parameters should be considered to improve the membrane performances, such as excellent biocompatibility, appropriate ultrafiltration rate, and effective clearance of the t...
متن کاملChallenges, applications, and recent advances of protein-ligand docking in structure-based drug design.
The docking methods used in structure-based virtual database screening offer the ability to quickly and cheaply estimate the affinity and binding mode of a ligand for the protein receptor of interest, such as a drug target. These methods can be used to enrich a database of compounds, so that more compounds that are subsequently experimentally tested are found to be pharmaceutically interesting....
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Toxoplasma gondii was first identified more than 100 years ago in the tissues of birds and mammals. In 1908 Nicolle and Manceoux described it for the first time in the gundi (Ctenodactylus gundi), a North African rodent, in tachyzoite forms. At the same time, Splendore in Brazil, identified the parasite in rabbit tissues. Due to its bow-like shape (Greek: Toxo = Arc) the genus was named Toxopla...
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ژورنال
عنوان ژورنال: Current Opinion in Virology
سال: 2013
ISSN: 1879-6257
DOI: 10.1016/j.coviro.2013.05.010